bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
Khresmoi - new !
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2018: S A J J M A M F J
2017: D N O S

 
  Other news for:
Brain
Multiple Sclerosis
 Resources from HONselect
Doctors Discover New Type of Multiple Sclerosis

By Robert Preidt

THURSDAY, Aug. 23, 2018 (HealthDay News) -- A new subtype of multiple sclerosis (MS) has been identified by researchers, and the discovery changes understanding of the disease.

MS has long been considered a disease of the brain's white matter, where immune cells destroy the fatty protective covering (myelin) on nerve cells. The destruction of myelin (demyelination) is linked to nerve cell death that leads to progressive disability in MS patients.

However, the newly identified subtype of MS -- called myelocortical MS (MCMS) -- features the loss of neurons but no damage to the brain's white matter.

In the study, researchers analyzed brain tissue from 100 MS patients who donated their brains after death. The investigators found that 12 of the brains did not have white matter demyelination.

While alive, MRI brain scans of those 12 patients were indistinguishable from those with traditional MS, the study authors said. That's because part of the neurons were swollen in those 12 patients and looked like typical MS lesions caused by white matter myelin loss. Diagnosis of MCMS was only possible after death.

The findings, published online Aug. 21 in The Lancet Neurology, show that neuron loss and demyelination can occur independently in MS. This highlights the need for more sensitive MRI scans, according to the researchers.

"This study opens up a new arena in MS research. It is the first to provide pathological evidence that neuronal degeneration can occur without white matter myelin loss in the brains of patients with the disease," said team leader Bruce Trapp. He is chair of the Lerner Research Institute department of neurosciences at the Cleveland Clinic.

"This information highlights the need for combination therapies to stop disability progression in MS," Trapp said in a Cleveland Clinic news release.

According to another research team member, Dr. Daniel Ontaneda, "The identification of this new MS subtype highlights the need to develop more sensitive strategies for properly diagnosing and understanding the pathology of MCMS." Ontaneda is clinical director of the brain donation program at Cleveland Clinic's Mellen Center for Treatment and Research in MS.

"We are hopeful these findings will lead to new tailored treatment strategies for patients living with different forms of MS," he added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more on multiple sclerosis.

SOURCE: Cleveland Clinic, news release, Aug. 21, 2018

Copyright © 2018 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=736961

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Multiple Sclerosis
Brain
Sclerosis
Neurons
Research Personnel
Myelin Sheath
Demyelinating Diseases
Death
Cells
Therapeutics
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact