bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
Khresmoi - new !
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2018: N O S A J J M A M F J
2017: D N

 
  Other news for:
Breast Neoplasms
Diabetes Mellitus
Hereditary Diseases
Genetics
 Resources from HONselect
Gene Test Predicts Risk of 5 Common Diseases

By Robert Preidt

TUESDAY, Aug. 14, 2018 (HealthDay News) -- A new type of genetic analysis could identify millions of Americans at high risk for five serious and common diseases, researchers report.

The diseases include coronary artery disease, the heart rhythm disorder atrial fibrillation, type 2 diabetes, inflammatory bowel disease and breast cancer.

Researchers tested and validated the genetic risk score on data from more 400,000 people in the UK Biobank.

While this method used British data, the results suggest that up to 25 million people in the United States may have more than triple the normal likelihood of developing coronary artery disease, and that millions more may have a similar increased risk for the other conditions, based on genetics alone.

The analysis of millions of locations on the genome could help gauge the likelihood of these conditions long before any symptoms appear, perhaps enabling early prevention or treatment, according to the researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and Harvard Medical School.

"We've known for a long time that there are people out there at high risk for disease based just on their overall genetic variation," study senior author Sekar Kathiresan said in an institute news release.

"Now, we're able to measure that risk using genomic data in a meaningful way. From a public health perspective, we need to identify these higher-risk segments of the population so we can provide appropriate care," he said.

Kathiresan is director of the institute's Cardiovascular Disease Initiative and the Center for Genomic Medicine at MGH.

The study was published Aug. 13 in the journal Nature Genetics.

The results are largely based on data from people of European descent, and broader studies of other ethnic groups are needed, the researchers noted.

Even so, the study authors said this approach needs to be considered for use in clinical care.

"We envision polygenic risk scores as a way to identify people at high or low risk for a disease, perhaps as early as birth, and then use that information to target interventions -- either lifestyle modifications or treatments -- to prevent disease," Kathiresan explained.

He added that one day soon patients may know their individual risk score for heart attack, similar to the way they can know their cholesterol number now.

More information

The U.S. National Human Genome Research Institute has more on genetic testing.

SOURCE: Broad Institute, news release, Aug. 13, 2018

Copyright © 2018 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=736724

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Risk
Research Personnel
Heart
Breast Neoplasms
Breast
Therapeutics
Neoplasms
Coronary Arteriosclerosis
Arteries
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact