A population of organisms, cells, viruses, or DNA molecules that is derived from the
replication of a single genetic progenitor. In the case of , each B-cell has
a typical and so all the cells which descend from one B-cell (the clone) have the same Ig.
Typically, a cancer is a clone of cells.
A mechanism whereby the loss of
of a particular specificity is due to contact with either "self" or
artificially introduced .
Clonal Selection Theory
Also known as Burnett theory, clonal selection theory states that the specificity and diversity of an
immune response are the result of selection by an of specifically reactive
clones from a large repertoire of preformed lymphocytes, each with individual
Literally, coming from a single clone. A clone is the progeny of a single cell.
In immunology, monoclonal generally describes a preparation of antibody that is
monogenous, or cells of a single specificity.
Laboratory-produced antibodies, which can be programmed to react against a specific
antigen in order to suppress the immune response.