A type of (white blood cell), also called a granular leukocyte, filled with granules of toxic chemicals, that can
Basophils are responsible for the symptoms of allergy.
Despite similarities, basophils appear to be a distinct cell type from .
Basophils are derived from
and contain granules that bind basic dyes. They are capable of synthesizing many of the same
as . Both express the same high
for Fce receptors (FceRI) and can be triggered by
binding to . Basophils, like other inflammatory , enter tissues only when they are recruited into inflammatory sites. Basophils, like
, express a number of adhesion molecules important for homing, such as
LFA-1 (CD11aCD18), Mac-1 (CD11bCD18) and CD44.
When basophils are triggered, they release two kinds of :
1. Preformed granule-associated mediators such as , , ,
2. Newly-generated mediators ,
and , made from in surrounding tissues.