H.D. Appelman

The Esophageal Mucosa / Mucosa and histology Is the presence of specialized epithelium necessary for the diagnosis of Barrett's esophagus? H.D. Appelman (Ann Arbor)

The Esophageal Mucosa / Mucosa and histology Apart from the specialized mucosal type, how can Barrett's mucosa be distinguished from the normal cardia mucosa? H.D. Appelman (Ann Arbor)

The Esophageal Mucosa / The adenocarcinomatous mucosa What are the minimal criteria for the biopsy diagnosis of well-differentiated adenocarcinomas? H.D. Appelman (Ann Arbor)

The Esophageal Mucosa / The adenocarcinomatous mucosa What is the histologic differential diagnosis for Barrett's carcinoma? H.D. Appelman (Ann Arbor)

Primary Motility Disorders of the Esophagus / Achalasia (hypomotility) is the best known entity Do the nerve alterations point to a neurogenic pathogenesis ? H.D. Appelman (Ann Arbor)

Primary Motility Disorders of the Esophagus / Achalasia (hypomotility) is the best known entity What are the morphologic expressions of achalasia in the esophagus and what are its morphologic complications ? H.D. Appelman (Ann Arbor)

Primary Motility Disorders of the Esophagus / Achalasia (hypomotility) is the best known entity Is the role of defective extrinsic and intrinsic innervation established ? H.D. Appelman (Ann Arbor)

Primary Motility Disorders of the Esophagus / Diffuse esophageal spasms (Corkscrew esophagus) What are the histologic features of diffuse esophageal spasm (DES) ? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Esophageal columnar metaplasia (Barrett s esophagus) What is the value of brush cytology in the diagnosis of non-dysplastic Barrett's esophagus? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Adenocarcinomas at the EGJ Do all adenocarcinomas at or near the esophagogastric junction have the same epidemiologic characteristics? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Adenocarcinomas at the EGJ Are there minimal criteria for the confident or unequivocal diagnosis of invasive carcinoma in the lamina propria both in Barrett's mucosa and in squamous mucosa? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Adenocarcinomas at the EGJ Can adenocarcinomas of the cardia and short segment of Barrett's mucosa be differentiated morphologically? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Achalasia What is the aspect of ganglion cells in the proximal stomach, that is, are the ganglion cells in the cardia in achalasia normal or not? H.D. Appelman (Ann Arbor)

The Esophagogastric Junction / Achalasia What is the histologic natural history of achalasia? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Etiology and origins of Barrett's epithelium Is cardiac mucosa normal or is it metaplastic? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Diagnosis What is the cause and significance of intestinal metaplasia distal to the Z-line? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Diagnosis What is the correlation between foveolar hyperplasia in the cardia and Barrett's esophagus? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Short Barrett's esophagus Barrett's esophagus is a family of metaplasias: are there genetic markers that correlate with different cell types in Barrett's metaplasia? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Dysplasia Are there specific morphometric features, particularly architectural, that correlate with different grades of dysplasia? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Screening and surveillance Do the current data support that an endoscopic-biopsy surveillance program prevents or does not prevent cancer in Barrett's mucosa? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Adenocarcinomas What is the acceptable definition of cardiac carcinoma? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / Adenocarcinomas What are the histologic criteria for the diagnosis of incipient invasion in Barrett's mucosa with high-grade dysplasia? H.D. Appelman (Ann Arbor)

Barrett's Esophagus / The definition of Barrett's esophagus Consensus of a Panel at the end of the 6th OESO World Congress A. Watson (Chairman), R.E. Sampliner, H.D. Appelman, S.J. Spechler, N.A. Shepherd

Barrett's Esophagus / Diagnosis What is the meaning of "mosaic" sucrase-isomaltase staining found in Barrett's epithelium? D.G. Beer, H.D. Appelman (Ann Arbor)