The changing pattern of adenocarcinoma of the EGJ
P.I. Reed (Slough) Full article (members only)

The epidemiology of adenocarcinoma of the esophagus and gastric cardia in the North West of England
J.P. Byrne (Dublin), J.M. Parry, C.B.J. Woodman, S.E.A. Attwood (Salford) Full article (members only)

What is the role of dietary intake in their development?
L.H. Bernstein, A. Wu (Los Angeles) Full article (members only)

Is the increasing use of drug therapy for reflux esophagitis a possible cause of sustained mitotic stimulation, eventually promoting esophageal carcinogenesis?
G. Willems, A. De Backer, 0. Peeters, Y. Van Nieuwenhove (Brussels) Full article (members only)

Is it possible to evaluate the rate of late-developed adenocarcinomas on Barrett's esophagus after successful AR repair?
F. Johnsson (Lund) Full article (members only)

Do all adenocarcinomas at or near the EGJ have the same epidemiologic characteristics?
H.D. Appelman (Ann Arbor) Full article (members only)

Could the rising frequency of cancer at the EGJ be related to undetected short-segment Barrett's esophagus?
S.J. Spechler (Dallas) Full article (members only)

What are the experimental data on the relationship between gastric or duodenal reflux and esophageal adenocarcinomas?
S.E.A. Attwood (Salford), J.P. Byrne (Dublin) Full article (members only)

How should the increasing incidence of adenocarcinomas of EGJ compared to cardia adenocarcinoma be interpreted?
G.R. Locke III (Rochester, MN) Full article (members only)

Pathology

Are there minimal criteria for the confident or unequivocal diagnosis of invasive carcinoma in the lamina propria both in Barrett's mucosa and in squamous mucosa?
H.D. Appelman (Ann Arbor) Full article (members only)
R.H. Riddell (Hamilton) Full article (members only)

Can adenocarcinomas of the cardia and short segment of Barrett's mucosa be differentiated morphologically?
H.D. Appelman (Ann Arbor) Full article (members only)

Is mediastinal lymph node involvement to be considered as a stage IV disease?
T. Lerut (Leuven) Full article (members only)

Are all carcinomas arising immediately above, immediately below and within the gastroesophageal junction region the same?
R.A. Hinder (Jacksonville), N. Katada, R.J. Lund, G. Perdikis, C.J. Filipi (Omaha) Full article (members only)

Is there a difference in prognosis between carcinoma of the cardia and Barrett's carcinoma?
J. Johansson (Lund) Full article (members only)

Has a metaplasia dysplasia-carcinoma sequence been identified for carcinoma of the cardia?
S.R. Hamilton (Baltimore) Full article (members only)

Is there evidence of a common cell type of origin for adenocarcinomas arising in Barrett's esophagus and the gastric cardia?
R.S.J. Thomas (Melbourne) Full article (members only)

What is the role of suppression of the T-lymphocyte function?
G.C. O'Sullivan, M.G. O'Brien, J. O'Connell, J.K. Collins, F. Shanahan (Cork) Full article (members only)

Endoscopic treatments

How may EUS influence the therapeutic approach?
Y. Murata, S. Suzuki, H. Ogma, Y. Kitamura, H. Ide, H. Suzuki (Tokyo) Full article (members only)

Is endoesophageal MRI likely to improve staging of adenocarcinomas at the EGJ?
H. van Overhagen, J. Stoker (Rotterdam) Full article (members only)

Is there a place for endoscopic mucosectomy in early cancers of the cardia or EGJ?
T. Kawano, M. Endo (Tokyo) Full article (members only)

What are the indications and results of endoscopic resection of early esophageal cancer?
M. Endo, T. Kawano, H. Inoue (Tokyo) Full article (members only)

In cases of endoscopic mucosal resection, should EUS evaluation by a miniature probe be recommended to make the indication more accurate?
T. Kawano, M. Endo (Tokyo) Full article (members only)

When is photodynamic therapy indicated for adenocarcinomas on Barrett's esophagus?
P. Spinelli, M. Dal Fante, A. Mancini (Milan) Full article (members only)

Is laser application likely to be improved by the use of novel devices?
E.J. Fricker (Sayre) Full article (members only)

Surgical treatments

What is the value of preoperative laparoscopy in the management of adenocarcinoma of the cardia?
L. Bonavina, R. Incarbone, A. Peracchia (Milan) Full article (members only)

Should histological differentiation induce specific modifications in the resection of adenocarcinomas of the GEJ?
J. Fass, B. Dreuw, K. Ophoff, V. Schumpelick (Aachen) Full article (members only)

What should be the extent of esophageal and gastric resection?
M. Endo (Tokyo) Full article (members only)

Is there any anatomic justification for partial esophagectomy in cancer of the cardia?
R. Sarrazin (Grenoble) Full article (members only)

The left thoracoabdominal approach for adenocarcinoma of the EGJ
T.H. Gouge (New York) Full article (members only)

The endoesophageal pull-through
F. Saidi (Tehran) Full article (members only)

When could bilateral thoracotomy be envisaged in lower esophageal cancer?
K. Iwase, W. Kamiike, T. Kido, T. Takao, H. Matsuda (Osaka) Full article (members only)

Multimodality treatments

What can be expected from a multimodality approach to adenocarcinomas of the esophagus?
D.P. Kelsen (New York) Full article (members only)

What is currently the most efficient combination chemotherapy?
J. Rouëssé, F. Cvitkovic (Saint-Cloud) Full article (members only)

Are adenocarcinomas of the cardia resistant, as gastric cancers, to quinone anti-cancer drugs and radiation therapy?
R. Izutani, S. Asano, M. Imano, M. Kato, H. Ohyanagi (Osaka), J. Chihara (Akita) Full article (members only)

What is the updated evaluation of the results of radiotherapy or brachytherapy in adenocarcinomas of the EGJ? How can the tumor response after irradiation be evaluated?
B.G. Taal, B.M.P. Aleman, H. Boot (Amsterdam) Full article (members only)

What benefit can be expected from brachytherapy in adenocarcinomas of the EGJ?
B.G. Taal (Amsterdam) Full article (members only)

What is the future prospect of gene therapy utilising p53?
D.S. Schrump, J.A. Roth (Houston) Full article (members only)

Is there a correlation between specific non molecular morphologic features of Barrett's carcinoma and prognosis?
K. Geboes, N. Ectors (Leuven) Full article (members only)

Is the expression of c-erb B-2 oncogene protein in tumor cells of independent prognostic importance in Barrett's carcinoma?
J.F. Fléjou (Paris) Full article (members only)