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What You Need to Know About Antidepressants
They work by affecting brain chemicals that regulate mood, FDA explains

By Mary Elizabeth Dallas

FRIDAY, June 2, 2017 (HealthDay News) -- Medication can help millions of people who struggle with depression, according to the U.S. Food and Drug Administration.

Depression affects some 350 million people worldwide. It's a serious illness and a major cause of disability. But its symptoms can be mistaken for other health issues and some people are afraid to seek help, the FDA said.

Not everyone with depression needs medicine, the agency said. But drugs used to treat it -- antidepressants -- can help ease symptoms, such as:

  • Depressed mood,
  • Loss of interest in normally enjoyable activities,
  • Changes in appetite or weight,
  • Trouble sleeping or sleeping too much,
  • Loss of energy or fatigue,
  • Restlessness,
  • Feelings of worthlessness or excessive guilt,
  • Problems thinking, focusing or making decisions,
  • Thoughts of death or suicide.

Doctors consider these symptoms -- as well as a patient's medical history, behavior and mental status -- to diagnose depression and rule out other health issues, including thyroid disease and Parkinson's disease.

Doctors should also evaluate patients for bipolar disorder, which can cause major mood swings. Giving antidepressants to someone with bipolar disorder could lead to psychosis, according to the FDA.

Antidepressants help treat depression by changing brain chemicals called neurotransmitters -- such as serotonin, norepinephrine and dopamine -- that help regulate mood.

There are several different types of antidepressants, which affect different neurotransmitters in different ways. Antidepressants include:

  • Selective serotonin reuptake inhibitors (SSRIs), including Prozac (fluoxetine), Celexa (citalopram) and Paxil (paroxetine),
  • Serotonin norepinephrine reuptake inhibitors (SNRIs), including Effexor (venlafaxine) and Cymbalta (duloxetine),
  • Tricyclic antidepressants (TCAs), including Elavil (amitriptyline), Tofranil (imipramine) and Pamelor (nortriptyline),
  • Monoamine oxidase inhibitors (MAOIs), including Nardil (phenelzine) and Parnate (tranylcypromine),
  • Other antidepressants include Remeron (mirtazapine) and Wellbutrin (buproprion).

"Some evidence shows that the most effective way to treat many patients with depression is through both talk therapy and prescribed antidepressant medication," Dr. Mitchell Mathis, director of the FDA's division of psychiatry products, said in an agency news release.

Taking antidepressants may cause complications, including birth defects and high blood pressure. Other possible side effects include:

  • Nausea and vomiting,
  • Weight gain,
  • Diarrhea,
  • Sleeping problems,
  • Sexual problems.

It's important for patients to work with their doctor to find the best treatment for them, Mathis said.

But medication won't ease depression overnight, the FDA cautioned. Most patients must take their prescribed drugs for several weeks before they fully take effect.

And people who take antidepressants should not stop without talking to their doctor first -- even if they feel better. Suddenly discontinuing this medicine could cause depression to return or lead to withdrawal symptoms, such as anxiety and irritability, according to the FDA.

The FDA requested drug makers to put a warning label on these drugs about the increased risk of suicidal thinking or behavior when children, teens and young adults up to age 24 start treatment or their dosage increases.

If you have suicidal thoughts or know someone who does, or you observe suicidal behaviors, seek immediate medical help. Or call the confidential and toll-free National Suicide Prevention Lifeline at 800-273-TALK (8255).

More information

The U.S. National Institute of Mental Health has more about treatment for depression.

SOURCE: U.S. Food and Drug Administration, news release

Copyright © 2017 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=722533

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Depression
Affect
Therapeutics
Serotonin
Brain
Thyroid Gland
Specialty Chemicals and Products
Behavior
Bipolar Disorder
Thinking
Tranylcypromine
Imipramine
Norepinephrine
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


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