bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
Khresmoi - new !
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2017: O S A J J M A M F J
2016: D N O

 
  Other news for:
Brain Neoplasms
Neoplasms
Drug Therapy
 Resources from HONselect
Vaccine Targeting Brain Tumors Seems Safe in Study
Combo therapy may also extend survival of glioblastoma patients, but more research needed

By Robert Preidt

FRIDAY, April 14, 2017 (HealthDay News) -- An experimental vaccine therapy shows promise in treating people with deadly glioblastoma brain cancer, researchers behind a small, preliminary study report.

With current standard care, half of glioblastoma patients die within 15 months of diagnosis.

Four of the 11 patients in this study survived for more than five years after vaccine/chemotherapy treatment, the Duke Cancer Institute research team said.

"This is a small study, but it's one in a sequence of clinical trials we have conducted to explore the use of an immunotherapy that specifically targets a protein on glioblastoma tumors," said lead author Dr. Kristen Batich.

"While not a controlled efficacy study, the survival results were surprising, and they suggest the possibility that combining the vaccine with a more intense regimen of this chemotherapy promotes a strong cooperative benefit," she added in a Duke University news release.

The trial -- the first of three required for U.S. approval -- was set up to test the safety of the chemotherapy/vaccine combination in 11 patients. Patients received an intensified dose of the chemotherapy drug temozolomide, followed by at least six vaccine injections. The vaccine treatments were well-tolerated, the researchers said.

The vaccine therapy targets cytomegalovirus (CMV) proteins, which are plentiful in glioblastoma tumors, according to the study authors.

"Our strategy was to capitalize on the immune deficiency caused by the temozolomide regimen," Batich said. "It seems counter-intuitive, but when the patient's lymphocytes are depleted, it's actually an optimal time to introduce the vaccine therapy. It basically gives the immune system marching orders to mount resources to attack the tumor."

Lymphocytes are white blood cells that form part of the immune system.

The study's senior author, Dr. John Sampson, said the findings support further study of this approach in larger clinical trials. Sampson is chair of neurosurgery at Duke.

The study was published online April 14 in the journal Clinical Cancer Research.

More information

The American Brain Tumor Association has more on glioblastoma.

SOURCE: Duke University, news release, April 14, 2017

Copyright © 2017 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=721591

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Neoplasms
Brain
Brain Neoplasms
Glioblastoma
Drug Therapy
Lymphocytes
Therapeutics
Research Personnel
Immune System
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact