bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
Khresmoi - new !
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2017: O S A J J M A M F J
2016: D N O

 
  Other news for:
Acquired Immunodeficiency Syndrome
 Resources from HONselect
Doctors Seeing More HIV Patients With Multidrug Resistance
People resistant to older medication also have problems with newer drug, study finds

By Robert Preidt

THURSDAY, Dec. 1, 2016 (HealthDay News) -- A significant number of people with HIV have strains of the AIDS-causing virus that are resistant to both older and newer drugs, researchers report.

The researchers looked at 712 HIV patients worldwide whose infection was not controlled by antiretroviral drugs. They found that 16 percent of patients whose infection was resistant to modern drugs had HIV mutations linked with resistance to older drugs called thymidine analogues.

Among patients whose HIV had this mutation, 80 percent were also resistant to tenofovir, the main drug in most modern HIV treatment and prevention programs, the researchers reported.

The findings were published in the Nov. 30 issue of The Lancet Infectious Diseases journal.

"We were very surprised to see that so many people were resistant to both drugs, as we didn't think this was possible," study lead author Ravi Gupta, of University College London, said in a school news release.

"Mutations for thymidine analogue resistance were previously thought to be incompatible with mutations for tenofovir resistance, but we now see that HIV can be resistant to both at once. This emphasizes the need to check the genetic profile of patient's virus before prescribing first-line treatments, as they may have already developed resistance to other treatments that they did not mention having taken," Gupta said.

Drug resistance typically occurs when patients fail to take their medications as directed by their doctor.

"To prevent these multi-resistant strains from developing, we need cheap, reliable systems to assess people before treatment," he said.

What's needed, Gupta said, are easy-to-use resistance-testing kits to help screen for drug resistance before giving treatment. This would also help doctors to "monitor HIV drug resistance globally more effectively," he said.

"However, until such kits are widely available, we could test the amount of virus in the bloodstream before and after giving treatment. Although not as precise as resistance testing, this could help us to detect treatment failure earlier and switch patients to second-line drugs," he added.

If a patient's HIV becomes resistant to first-line drugs, they're given second-line drugs that cause more side effects. But many rural patients don't have access to second-line drugs, so trying to preserve the effectiveness of first-line treatments is crucial, Gupta explained.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more on HIV treatment.

SOURCE: University College London, news release, Nov. 30, 2016

Copyright © 2016 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=717334

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Therapeutics
Specialty Chemicals and Products
Research Personnel
Infection
Communicable Diseases
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact