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Pigs' Hearts Beat for a Year in Baboons' Abdomens
Studies may one day lead to use of animal organs for human transplantation

By Robert Preidt

WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Pigs' hearts transplanted into baboons survived for more than a year, which is twice as long as previously achieved, researchers report.

The work is part of efforts to find ways to use animal organs to shorten transplant waiting lists.

In this study, scientists transplanted hearts from genetically engineered piglets into baboons' abdomens. The genetic engineering and new methods of suppressing the baboons' immune system response are what enabled the hearts to survive for more than a year.

The genetic manipulation involved removing genes that trigger attack by the human immune system, and inserting genes that are more compatible, according to the study published recently in The Journal of Thoracic and Cardiovascular Surgery.

The next step is to replace the baboons' hearts with the genetically engineered pigs' hearts to find out if the transplanted hearts can keep the baboons alive.

About 3,000 people in the United States are on the waiting list for a heart transplant, but only 2,000 donor hearts become available each year, according to background information in a journal news release. Transplantation using animal organs (xenotransplantation) is seen as a possible way to save the lives of people on transplant waiting lists.

"Until we learn to grow organs via tissue engineering, which is unlikely in the near future, xenotransplantation seems to be a valid approach to supplement human organ availability. Despite many setbacks over the years, recent genetic and immunologic advancements have helped revitalized progress in the xenotransplantation field," lead investigator Dr. Muhammad Mohiuddin, of the Cardiothoracic Surgery Research Program at the U.S. National Heart, Lung, and Blood Institute, said in the news release.

Pigs are being studied because their anatomy is compatible with humans and they are a widely available source of organs, among other reasons. However, animal research does not always pan out in humans.

More information

The U.S. Food and Drug Administration has more about xenotransplantation.

SOURCE: The Journal of Thoracic and Cardiovascular Surgery, news release, Aug. 18, 2014

Copyright © 2014 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=690895

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Heart
Abdomen
Transplants
Transplantation, Heterologous
Animal Structures
Lead
Transplantation
Research Personnel
Immune System
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


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