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Tough-to-Abuse Formulation of Oxycodone Approved
Targiniq includes naloxone, which blocks euphoric effect if pill is crushed or broken

By Scott Roberts

THURSDAY, July 24, 2014 (HealthDay News) -- Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has been approved by the U.S. Food and Drug Administration as a long-term, around-the-clock treatment for severe pain when other therapies are ineffective or unavailable.

The long-acting form of oxycodone, an opioid painkiller, has properties that are designed to deter abuse of the drug by snorting or injection, the FDA said in a news release. Targiniq contains naloxone, designed to block the euphoric effects of oxycodone, the agency said.

Targiniq can still be abused by taking too many pills, the FDA warned, stressing that an overdose could cause death.

The drug is not meant for as-needed pain relief, the agency said, repeating its warning of the potential for abuse and addiction.

Targiniq ER was evaluated in a clinical study of 601 people with chronic lower back pain. The most common side effects were nausea and vomiting.

The agency said it is requiring the manufacturer to conduct additional post-marketing studies to assess the drug's risks of misuse, addiction and abuse.

Targiniq ER is manufactured by Purdue Pharma, based in Stamford, Conn.

More information

To learn more about this approval, visit the FDA.

Copyright © 2014 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=690112

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Pain
Back Pain
Substance-Related Disorders
Therapeutics
Nausea
Low Back Pain
The list of medical terms above are retrieved automatically from the article.

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