bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
All Web sites
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2014: J J M A M F J
2013: D N O S A J

 
  Other news for:
Eye Diseases
Glaucoma
Hormone Replacement Therapy
Sex Hormones
Menopause
Postmenopause
 Resources from HONselect
Postmenopausal Estrogen Therapy Tied to Lower Glaucoma Risk
Effect seen for women on estrogen-only treatment in study, but experts say more research is needed

By Kathleen Doheny
HealthDay Reporter

THURSDAY, Jan. 30, 2014 (HealthDay News) -- Women who take estrogen-only hormone-replacement therapy to relieve menopausal symptoms might also be reducing their risk for a common form of the eye disease glaucoma, according to new research.

"Ours is one of the first ... studies to find estrogen-containing hormone-replacement therapy was associated with a reduction in glaucoma risk," said study researcher Dr. Joshua Stein, an assistant professor of ophthalmology at the University of Michigan.

Other studies, however, have come up with conflicting results, Stein said. In his study, he looked at insurance-claims data for women aged 50 and older who were enrolled in a managed care plan for at least four years. The women visited an eye care provider at least twice from 2001 to 2009.

He evaluated information on more than 152,000 women, about 60,000 of whom had at least one prescription for estrogen-only therapy, he said. The others took a combination of estrogen and progesterone or estrogen plus an androgen (male hormone).

During the study period, about 2 percent of the women developed a common form of glaucoma known as primary open angle glaucoma, Stein said, which develops when pressure builds up in the eye. Glaucoma refers to a group of eye diseases that damage the optic nerve and can lead to blindness. Treatment can help preserve vision.

Each month of estrogen use reduced the risk of glaucoma by 0.4 percent, and that risk reduction accumulated over time, Stein said. After four years of continuous use, the reduction in risk would be about 19 percent, he said.

Although the researchers found an association between the use of estrogen-only therapy and a reduced risk for this form of glaucoma, they did not prove a cause-and-effect link. No link was found for the other hormone regimens.

The study was published online Jan. 30 in the journal JAMA Ophthalmology.

Estrogen might work by lowering the pressure or by protecting certain cells in the eye, the researchers said.

Hormone-replacement therapy has been linked with increased health risks, such as heart disease, breast cancer and stroke. One 10-year follow-up of the Women's Health Initiative estrogen-only trial, however, found a reversal of the health risks among women who'd had a hysterectomy.

The new study results do not suggest that reducing the risk of glaucoma is reason enough to take hormone replacement therapy, said Dr. Angela Turalba, a glaucoma specialist at the Massachusetts Eye and Ear Infirmary.

Rather, the findings may prompt drug companies to begin looking at estrogen as a glaucoma treatment, said Turalba, who reviewed the research. "The findings are most helpful in guiding research in drug development for hormone-based therapies to be used as neuro-protective agents," she said.

Stein agreed. He said the goal would be to encourage drug companies to develop topical estrogen derivatives and study them as a glaucoma-preventive therapy.

The focus of the study was on women, he said, so there is no way to know whether estrogen-based treatments would also help men reduce glaucoma risk.

More information

To learn more about glaucoma, visit the Glaucoma Research Foundation.

SOURCES: Joshua Stein, M.D., assistant professor of ophthalmology, University of Michigan, Ann Arbor; Angela Turalba, M.D., glaucoma specialist, Massachusetts Eye and Ear Infirmary, Boston; Jan. 30, 2014, JAMA Ophthalmology, online

Copyright © 2014 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=684350

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Glaucoma
Risk
Women
Eye
Hormones
Therapeutics
Research Personnel
Eye Diseases
Ear
Hormone Replacement Therapy
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact