bannerHON
img
HONnews
HONnews
img PATIENT / PARTICULIER img PROFESSIONNEL DE SANTE img WEBMESTRE img
img
 
img
HONcode sites
All Web sites
HONselect
News
Conferences
Images

Themes:
A B C D E F G H I
J K L M N O P Q
R S T U V W X Y Z
Browse archive:
2014: S A J J M A M F J
2013: D N O S

 
  Other news for:
Down Syndrome
Genetics
Kidney Calculi
 Resources from HONselect
FDA Approves Genetic Test That Helps Explain Developmental Problems in Kids
Experts caution that it should only be given to young children when problems first appear

By Steven Reinberg
HealthDay Reporter

FRIDAY, Jan. 17, 2014 (HealthDay News) -- The U.S. Food and Drug Administration approved on Friday a first-of-its-kind blood test that can scan a child's genetic code and spot possible genetic explanations for developmental delays or intellectual disabilities.

The test can identify variations in chromosomes that are linked to such disorders as Down syndrome, DiGeorge syndrome and other developmental disabilities, the FDA said in a news release.

"This test is going to provide an additional diagnostic tool for treatment of children with identified developmental problems and disabilities," said Dr. Annemarie Stroustrup, an assistant professor of pediatrics and newborn medicine at Mount Sinai Hospital in New York City.

It could speed up the diagnosis of these problems, "which could open the door for better and more targeted treatment," Stroustrup said. "It will also give families a more accurate prognosis for children who have genetic causes for their developmental disability."

Stroustrup stressed, however, that the test isn't a screening tool to predict the future mental ability of a child. "It would be unethical to use it that way," she said.

"It's more of a diagnostic test for children who have pre-existing problems," Stroustrup said. Parents should wait until the child is a toddler and showing signs of developmental problems before considering this test, she added.

The test, called CytoScan Dx, analyzes a child's entire genome, the FDA said in the statement. Affymetrix Inc., based in Santa Clara, Calif., manufactures the test.

The FDA cautioned, however, that "the test results should only be used in conjunction with other clinical and diagnostic findings."

This recommendation is the most important part of Friday's announcement, said Rahil Briggs, director of Pediatric Behavioral Health Services at Montefiore Medical Center in New York City.

"I support all innovations that can reliably aid our ability to make accurate diagnoses, leading to appropriate interventions," Briggs said.

"However, any diagnosis of developmental delay requires multiple sources of information, including clinical observation by a trained professional," Briggs added.

Between 2 percent and 3 percent of U.S. children have some type of intellectual disability. Many of these disabilities, such as Down syndrome and DiGeorge Syndrome, are associated with chromosomal variations, according to the U.S. National Institutes of Health and the American Academy of Pediatrics.

In approving the test, the FDA found that the screen could "adequately" detect chromosome variations in areas of genetic code linked with intellectual and developmental disabilities.

The agency also compared the new test with existing tests commonly used for identifying a particular developmental delay or intellectual disability. That comparison showed that the new test was better at spotting certain chromosomal abnormalities.

Dr. David Mendez, a neonatologist at Miami Children's Hospital, advised parents to be cautious about having such a test.

"Any genetic testing you do of your child has to be in consultation with a pediatric geneticist," he said.

Mendez said he'd also restrict the test to children who already show signs of a developmental problem.

More information

Visit the U.S. Centers for Disease Control and Prevention for more on child development.

SOURCES: Rahil Briggs, Psy.D., assistant professor, pediatrics, and director, Pediatric Behavioral Health Services, Montefiore Medical Center, New York City; Annemarie Stroustrup, M.D., assistant professor, pediatrics and newborn medicine, Mount Sinai Hospital, New York City; David Mendez, M.D., neonatologist, Miami Children's Hospital; Jan. 17, 2014, news release, U.S. Food and Drug Administration

Copyright © 2014 HealthDay. All rights reserved. URL:http://consumer.healthday.com/Article.asp?AID=683998

Resources from HONselect: HONselect is the HON's medical search engine. It retrieves scientific articles, images, conferences and web sites on the selected subject.
Syndrome
Diagnosis
Mental Retardation
Developmental Disabilities
Therapeutics
Chromosomes
The list of medical terms above are retrieved automatically from the article.

Disclaimer: The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns. Do not use this information to diagnose or treat a health problem or disease without consulting a qualified healthcare professional.
Be advised that HealthDay articles are derived from various sources and may not reflect your own country regulations. The Health On the Net Foundation does not endorse opinions, products, or services that may appear in HealthDay articles.


Home img About us img MediaCorner img HON newsletter img Site map img Ethical policies img Contact