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  Antibody Dependant Cell Mediated Cytotoxicity Multimedia
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 Antibody-Dependent Cell Cytotoxicity

Antibody Dependant Cell Mediated Cytotoxicity (ADCC)
Type VI Hypersensitivity

Type VI reaction according to the Gell and Coombs Classification . A phenomenon in which target cells, coated with antibody, are destroyed by specialized killer cells ( NK cells , Killer T-cells and macrophages ), which bear receptors for the Fc portion of the coating antibody (Fc receptors). These receptors allow the killer cells to bind to the anti-body-coated target. Eosinophils kill helminths (parasitic larvae infections) by ADCC.

 

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  http://www.hon.ch/Library/Theme/Allergy/Glossary/type6.html Last modified: Fri Jun 28 2002