T-cell receptor (TCR)
T-cell receptors are membrane-bound proteins found on , which recognize
on the of .
T-cell Receptors differ from
that they cannot bind free antigens. For a T-cell receptor, the antigen must be presented on a
MHC protein. In
the case of T-cells, the antigen peptides must be presented on Class II MHC, and in the case of
, the antigen peptides must be presented on Class I MHC.
The T-cell antigen receptor consists of either an alpha/beta chain (TCR-2) or a gamma/delta chain (TCR-1)
associated with the CD3 molecular complex.