Allergy : A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Pollen Calendar

   More on this topic
Relevant sites from
HON's MedHunt:


  Interleukin1 Multimedia
from HONselect:


 Interleukin-1

Interleukin-1 (IL1)

IL1 is produced mainly by macrophages (most important source) as well as some other cell types. Locally, IL1 from stimulated macrophages stimulates cytokine and cytokine receptor production by T-cells as well as stimulating B-cell proliferation.

There are 2 forms of IL1: IL1alpha and IL1beta , both with the same activities but different structures. IL1alpha appears to be primarily membrane-associated while IL1beta can circulate. Both forms bind to the same receptors, of which there there are two types found on different cell types, for example T- and B-cells, macrophages, neutrophils , bone marrow cells, fat cells, bone cells (osteoclasts), brain cells, cells of the adrenal gland , vascular endothelial cells and smooth muscle cells (amongst others).

These secretions are involved in inflammation , accounting in part for such inflammatory characteristics as vasodilation , cramps, fever and can produce a wasting syndrome called cachexia . Inducing adhesion molecule expression on vascular endothelium is part of the inflammation syndrome - IL1 induces ICAM 1 expression, while TNFalpha induces ELAM 1 expression on endothelium.

Corticosteroids , produced by the adrenals in response to signals from the brain (cortisone), inhibit the action of IL1 and are therefore used to reduce inflammation.

 

Home

About us

Site map

Search

HONewsletter

© HON

Contact

 

  http://www.hon.ch/Library/Theme/Allergy/Glossary/il1.html Last modified: Fri Jun 28 2002