A group of proteins with properties, capable of
enhancing and modifying the immune response. Interferon is released to
coat uninfected cells so that they don't become infected. Some
interferons induce antiviral activity, others enhance the immune response.
There are three main classes of interferon:
alpha , beta , and gamma .
All IFNs induce cell growth, activate CTL and NK cells as well as increasing
IFNalpha and beta bind to the same receptor while IFNgamma binds to another.
- IFNalpha is produced by
- IFNbeta is produced by virus-infected fibroflasts
(and some other cell types).
- IFNgamma is produced by stimulated and
. IFNgamma increases
II expression, activates
, and NK cells as well as
activating vascular endothelium, promoting T and differentiation and
synthesis. Also increases IgG2a and decreases
, G1, G2b and G3 (opposite of ).