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Parkinson Disease
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Synonym(s): Idiopathic Parkinson Disease / Lewy Body Parkinson Disease / Paralysis Agitans / Primary Parkinsonism / Idiopathic Parkinson's Disease / Lewy Body Parkinson's Disease / Parkinson Disease, Idiopathic / Parkinson's Disease / Parkinson's Disease, Idiopathic / Parkinson's Disease, Lewy Body / Parkinsonism, Primary
See also:
Lewy Bodies  Manganese Poisoning   

MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is Parkinson disease?
Parkinson disease is a progressive disorder of the central nervous system. The disorder affects several regions of the brain, including an area called the substantia nigra that controls balance and movement. Parkinson disease may also affect regions of the brain that regulate involuntary functions such as blood pressure and heart activity.
Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect t ...

How common is Parkinson disease?
Parkinson disease affects more than 1 million people in North America and more than 4 million people worldwide. In the United States, Parkinson disease occurs in approximately 13 per 100,000 people and about 50,000 new cases are identified each year. The number of cases is rising with the increasing age of the general population.


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  Web resources for "Parkinson Disease"
  English (69)  French (79)  German (17)  Spanish (21)    Italian (7)  Dutch (2)

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view the HON description of the site HONcode - Parkinson disease - Genetics Home Referenceghr.nlm.nih.gov 9
  view the HON description of the site Massachusetts General Hospital Functional and Stereotactic Neurosurgery Home Pageneurosurgery.mgh.harvard.edu 3
view the HON description of the site HONcode - Parkinson's Disease: MedlinePluswww.nlm.nih.gov 2
view the robot description of the site Parkinson's Disease - Parkinson's Disease Treatment - Better Medicinewww.wrongdiagnosis.com  
view the robot description of the site Learning About Parkinson's Diseasewww.genome.gov  
view the robot description of the site Parkinson's Disease Information Page: National Institute of Neurological Disorders and Stroke (NINDS)www.ninds.nih.gov 10
view the HON description of the site HONcode - Parkinson's Disease - What Is Parkinson's Disease? | ehealthMDwww.ehealthmd.com 7
view the HON description of the site HONcode - Parkinson's Diseasewww.fpnotebook.com 3
view the HON description of the site HONcode - Parkinson's Disease (PD) Parkinson's disease | Mayfield Clinicwww.mayfieldclinic.com 2
view the robot description of the site BBC - Health: Parkinson's disease www.bbc.co.uk  
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See also: - Lewy Bodies

Broader term(s): - Parkinsonian Disorders - Basal Ganglia Diseases - Brain Diseases - Central Nervous System Diseases - Nervous System Diseases - Neurodegenerative Diseases
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  Medical image(s) for "Parkinson Disease"
click below to enlargeParkinson's Disease - 3D Medical Animation
www.virtualrespiratorycentre.com
Copyright © Virtual Respiratory Centre Parkinson's Disease - 3D Medical Animation
click below to enlargeParkinson's treatment
www.parkinsonsinfo.com
Copyright © About Parkinson's Disease Parkinson's treatment
click below to enlargeVideo displaying an example of RIGIDITY in Parkinson's Disease
medweb.bham.ac.uk
Department of Neurology, Queen Elizabeth Hospital Video displaying an example of RIGIDITY in Parkinson's Disease
Copyright © Dr David Nicholl
click below to enlargeParkinson's Disease (PET)
neurosurgery.mgh.harvard.edu
Copyright © Massachusetts General Hospital Parkinson's Disease (PET)
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Broader term(s): - Brain Diseases - Nervous System Diseases
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  Medical News for "Parkinson Disease"
Parkinson's Drugs Tied to Compulsive Behaviors   (05/10/2010, HealthDay)
Voice Analysis May Allow Early Detection of Parkinson's   (04/30/2010, HealthDay)
Adding Surgery to Meds May Improve Life With Parkinson's   (04/29/2010, HealthDay)
Parkinson's Linked to Genetic Mutation   (04/02/2010, HealthDay)
Relief Sought for Secondary Parkinson's Symptoms   (03/15/2010, HealthDay)
Longtime Smokers May Find Protection From Parkinson's   (03/10/2010, HealthDay)
Melanoma Risk Higher in Parkinson's Patients   (03/08/2010, Reuters Health)
Extended-Release Mirapex Approved for Parkinson's Disease   (02/24/2010, HealthDay)
Ibuprofen May Help Stave Off Parkinson's   (02/17/2010, HealthDay)
Voice Problems May Affect Social Life in Parkinson's   (02/10/2010, HealthDay)
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Broader term(s): - Nervous System Diseases

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  Scientific articles from MEDLINE for "Parkinson Disease"
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy

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  Clinical Trials for "Parkinson Disease"
ClinicalTrials.gov - Linking patients to medical research

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See also: - Lewy Bodies

Broader term(s): - Parkinsonian Disorders - Basal Ganglia Diseases - Brain Diseases - Central Nervous System Diseases - Nervous System Diseases - Neurodegenerative Diseases

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  Medical Conferences/Events for "Parkinson Disease"
Jul 26
Jul 30
2015 CME - A Comprehensive Review of Movement Disorders for the Clinical Practitioner USA
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy


  Broader term(s):
      Diseases
          Nervous System Diseases
              Neurodegenerative Diseases 
              Central Nervous System Diseases
                  Movement Disorders
                      Parkinsonian Disorders 
                  Brain Diseases
                      Basal Ganglia Diseases
                          Parkinsonian Disorders 

MeSH 2010 © U.S. National Library of Medicine®.

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