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Parkinson Disease
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Synonym(s): Idiopathic Parkinson Disease / Lewy Body Parkinson Disease / Paralysis Agitans / Primary Parkinsonism / Idiopathic Parkinson's Disease / Lewy Body Parkinson's Disease / Parkinson Disease, Idiopathic / Parkinson's Disease / Parkinson's Disease, Idiopathic / Parkinson's Disease, Lewy Body / Parkinsonism, Primary
See also:
Lewy Bodies  Manganese Poisoning   

MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is Parkinson disease?
Parkinson disease is a progressive disorder of the central nervous system. The disorder affects several regions of the brain, including an area called the substantia nigra that controls balance and movement. Parkinson disease may also affect regions of the brain that regulate involuntary functions such as blood pressure and heart activity.
Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect t ...

How common is Parkinson disease?
Parkinson disease affects more than 1 million people in North America and more than 4 million people worldwide. In the United States, Parkinson disease occurs in approximately 13 per 100,000 people and about 50,000 new cases are identified each year. The number of cases is rising with the increasing age of the general population.


More information from the Genetics Home Reference Website
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  Web resources for "Parkinson Disease"
  English (78)  French (100)  German (22)  Spanish (31)  Portuguese (4)  Italian (14)  Dutch (9)

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view the HON description of the site HONcode - Parkinson disease - Genetics Home Referenceghr.nlm.nih.gov 9
view the HON description of the site HONcode - Parkinson's Diseasewww.fpnotebook.com 3
view the robot description of the site Functional and Stereotactic Neurosurgery Center - GateWay to Neurosurgery @ Massachusetts General Hospital - Harvard Medical Schoolneurosurgery.mgh.harvard.edu 4
view the HON description of the site HONcode - American Parkinson Disease Association Information and Referral Center of Minnesotawww.allina.com  
view the HON description of the site HONcode - Parkinson's Disease: MedlinePluswww.nlm.nih.gov 3
view the HON description of the site HONcode - Publications - Méridiens.orgwww.meridiens.org  
view the robot description of the site Update on Parkinson's Disease - April 15, 1999 - American Family Physicianwww.aafp.org 2
view the HON description of the site HONcode - Parkinson's disease - MayoClinic.comwww.mayoclinic.com  
view the HON description of the site HONcode - American Parkinson Disease Associationwww.parkinson.it  
view the HON description of the site HONcode - eMedicineHealth - experts in everyday emergencies, first aid and health informationwww.emedicinehealth.com  
view the robot description of the site Learning About Parkinson's Diseasewww.genome.gov 2
view the robot description of the site Parkinson's Disease Information Page: National Institute of Neurological Disorders and Stroke (NINDS)www.ninds.nih.gov 10
view the robot description of the site BBC - Health: Parkinson's disease www.bbc.co.uk 2
view the HON description of the site HONcode - Parkinson's Disease (PD) Parkinson's disease | Mayfield Clinicwww.mayfieldclinic.com 5
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See also: - Lewy Bodies

Broader term(s): - Parkinsonian Disorders - Basal Ganglia Diseases - Brain Diseases - Central Nervous System Diseases - Nervous System Diseases - Neurodegenerative Diseases
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  Medical image(s) for "Parkinson Disease"
click below to enlargeParkinson's Disease (PET)
neurosurgery.mgh.harvard.edu
Copyright © Massachusetts General Hospital Parkinson's Disease (PET)
click below to enlargeGenes and disease - immunofluorescent stain
www.ncbi.nlm.nih.gov
Copyright © National Center for Biotechnology Information Genes and disease - immunofluorescent stain
click below to enlargeParkinson's treatment
www.parkinsonsinfo.com
Copyright © About Parkinson's Disease Parkinson's treatment
Broader term(s): - Nervous System Diseases
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  Medical News for "Parkinson Disease"
Just One Concussion Could Raise Parkinson's Risk   (04/18/2018, HealthDay)
Clues to Parkinson's May Be Shed in Tears   (02/22/2018, HealthDay)
Brain 'Pacemaker' Might Help Slow Alzheimer's   (01/30/2018, HealthDay)
Neil Diamond Reveals Parkinson's Diagnosis   (01/23/2018, HealthDay)
Can Caffeine Levels in Blood Predict Parkinson's?   (01/03/2018, HealthDay)
Vigorous Exercise May Help Slow Parkinson's Disease   (12/11/2017, HealthDay)
Are Women With Parkinson's at a Disadvantage?   (12/08/2017, HealthDay)
Coffee Doesn't Help Parkinson's Motor Disorders   (09/28/2017, HealthDay)
Brain Disconnects Spotted in Parkinson's Patients With Visual Hallucinations   (09/28/2017, HealthDay)
Why Your Nose May Be Key to Parkinson's Risk   (09/06/2017, HealthDay)
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Broader term(s): - Nervous System Diseases

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  Scientific articles from MEDLINE for "Parkinson Disease"
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy

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  Clinical Trials for "Parkinson Disease"
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  Medical Conferences/Events for "Parkinson Disease"
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Broader term(s): - Neurodegenerative Diseases

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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy


  Broader term(s):
      Diseases
          Nervous System Diseases
              Neurodegenerative Diseases 
              Central Nervous System Diseases
                  Movement Disorders
                      Parkinsonian Disorders 
                  Brain Diseases
                      Basal Ganglia Diseases
                          Parkinsonian Disorders 

MeSH 2010 © U.S. National Library of Medicine®.

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