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Syndrome de Lesch-Nyhan
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Définition:
An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; . Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
Synonyme(s):
Déficit complet en HGPRT /
Déficit en hypoxanthine guanine phosphoribosyltransférase /
Déficit en hypoxanthine-guanine-phosphoribosyl-transférase /
Maladie de Lesch-Nyhan /
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(NLM)®
de l'INSERM (version française)
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MALADIES
Maladies métaboliques et nutritionnelles