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Hierarchy  - English - French - German - Spanish - Portuguese - Italian - Dutch    Prader-Willi Syndrome Definition: An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229) Synonym(s): Labhart-Willi Syndrome / Royer Syndrome / Labhart-Willi-Prader-Fanconi Syndrome / Royer's Syndrome / See also: Mental Retardation    MeSH 2010 © U.S. National Library of Medicine®. Browse - New search

More information from the Genetics Home Reference Website What is Prader-Willi syndrome? Prader-Willi syndrome is a complex genetic condition that affects many parts of the body. In infancy, this condition is characterized by weak muscle tone (hypotonia), feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite and chronic overeating (hyperphagia). As a result, most experience rapid weight gain leading to obesity. People with Prader-Willi syndrome typically have mental retardation or learning disabilities and behavioral problems. Many people with this disorder also h ... How common is Prader-Willi syndrome? Prader-Willi syndrome affects an estimated 1 in 10,000 to 25,000 people. More information from the Genetics Home Reference Website © Genetics Home Reference Browse - New search       Web resources for "Prader-Willi Syndrome"   English (20)  French (2)  German (4)  Spanish (5)  Portuguese (1)  Italian (1)   = Site with HON description   -   = Site with a robot description info: enter the site: (click below) domain of the site:   Prader-Willi syndrome Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com www.wrongdiagnosis.com   HONcode - Prader-Willi Syndrome: MedlinePlus www.nlm.nih.gov 2 HONcode - Prader-Willi syndrome - Genetics Home Reference ghr.nlm.nih.gov 2 BBC - Health: Prader-Willi syndrome www.bbc.co.uk   HONcode - Prader-Willi syndrome www.kumc.edu   rare-diseases — National Organization for Rare Disorders www.rarediseases.org 2 HONcode - Orphanet: Prader Willi syndrome www.orpha.net 3 Prader-Willi Syndrome Association (PWSA) of Victoria, Australia Home Page www.pws.asn.au   HONcode - Prader-Willi Syndrome www.fpnotebook.com   next results See also: - Mental Retardation Broader term(s): - Mental Retardation - Neurobehavioral Manifestations - Neurologic Manifestations - Nervous System Diseases - Abnormalities, Multiple - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders - Obesity - Overnutrition - Nutrition Disorders - Nutritional and Metabolic Diseases Browse - New search       Medical image(s) for "Prader-Willi Syndrome" No results for this term. Browse other medical images in HONmedia? Broader term(s): - Obesity - Nutrition Disorders Browse - New search       Medical News for "Prader-Willi Syndrome" No results for this term. More health news See also: - Mental Retardation Broader term(s): - Mental Retardation - Nervous System Diseases - Abnormalities Browse - New search       Scientific articles from MEDLINE for "Prader-Willi Syndrome"   - English - French - German - Spanish - Portuguese - Italian - Dutch     All recent articles  Therapy:  by recall    /  by precision  Diagnosis:  by recall    /  by precision  Etiology:  by recall    /  by precision  Prognosis:  by recall    /  by precision Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Browse - New search       Clinical Trials for "Prader-Willi Syndrome" ClinicalTrials.gov - Linking patients to medical research Prader-Willi Syndrome and Appetite Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome Nordic Study on the Effects of Growth Hormone (Norditropin SimpleXx) Treatment in Adults With Prader-Willi Syndrome Octreotide Therapy in Children and Young Adults With Prader-Willi Syndrome (PWS) Growth Hormone Use in Adults With Prader-Willi Syndrome   More results See also: - Mental Retardation Broader term(s): - Mental Retardation - Neurobehavioral Manifestations - Neurologic Manifestations - Nervous System Diseases - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders - Obesity - Overnutrition - Nutrition Disorders Browse - New search       Medical Conferences/Events for "Prader-Willi Syndrome" No results for this term. Consult HON's world-wide database of medical meetings Broader term(s): - Obesity Browse - New search       Refine the search for  "Prader-Willi Syndrome" Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy   Broader term(s):       Diseases           Nutritional and Metabolic Diseases               Nutrition Disorders                   Overnutrition                       Obesity        Diseases           Congenital, Hereditary, and Neonatal Diseases and Abnormalities               Genetic Diseases, Inborn                   Chromosome Disorders                Abnormalities                   Chromosome Disorders                    Abnormalities, Multiple        Diseases           Nervous System Diseases               Neurologic Manifestations                   Neurobehavioral Manifestations                       Mental Retardation  MeSH 2010 © U.S. National Library of Medicine®. Browse - New search

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