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De Lange Syndrome
Definition: A syndrome characterized by growth retardation, severe MENTAL RETARDATION, short stature, a low-pitched growling cry, brachycephaly, low-set ears, webbed neck, carp mouth, depressed nasal bridge, bushy eyebrows meeting at the midline, hirsutism, and malformations of the hands. The condition may occur sporadically or be associated with an autosomal dominant pattern of inheritance or duplication of the long arm of chromosome 3. (Menkes, Textbook of Child Neurology, 5th ed, p231)

Synonym(s): Brachmann-De Lange Syndrome / Cornelia De Lange Syndrome / De Lange's Syndrome / Typus Degenerativus Amstelodamensis / Amstelodamensis, Typus Degenerativus / Brachmann De Lange Syndrome / Syndrome, Brachmann-De Lange / Syndrome, De Lange / Syndrome, De Lange's
See also:
Mental Retardation   

MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is Cornelia de Lange syndrome?
Cornelia de Lange syndrome is a developmental disorder that affects many parts of the body. The features of this disorder vary widely among affected individuals and range from relatively mild to severe.
Cornelia de Lange syndrome is characterized by slow growth before and after birth, mental retardation that is usually severe to profound, abnormalities involving the arms and hands, and distinctive facial features. The facial differences include thin, arched eyebrows; long eyelashes; low-set ears; small, widely spaced teeth; and a small, upturned nose. M ...

How common is Cornelia de Lange syndrome?
Although the exact incidence is unknown, Cornelia de Lange syndrome likely affects 1 in 10,000 to 30,000 newborns.


More information from the Genetics Home Reference Website
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  Web resources for "De Lange Syndrome"
  English (12)    German (1)        

= Site with HON description   -   = Site with a robot description
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view the HON description of the site HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Merwww.asnom.org  
view the HON description of the site HONcode - Cornelia de Lange syndrome - Genetics Home Referenceghr.nlm.nih.gov 2
view the robot description of the site BBC - Health: Cornelia de Lange syndrome www.bbc.co.uk  
view the robot description of the site rare-diseases — National Organization for Rare Disorderswww.rarediseases.org 5
view the HON description of the site HONcode - Orphanet: Cornelia de Lange syndromewww.orpha.net 6
view the robot description of the site Whonamedit - Brachmann-de Lange syndromewww.whonamedit.com  
view the HON description of the site HONcode - Multiple Human Cognitive Disorders Linked By A Common Threadnursing-resource.com  
view the HON description of the site HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Merwww.asnom.org  
view the HON description of the site HONcode - Microcephaly: MedlinePlus Medical Encyclopediawww.nlm.nih.gov 2
view the robot description of the site Cornelia de Lange Syndrome (CdLS) Foundation, Inc.www.cdlsusa.org  
 
 

See also: - Mental Retardation

Broader term(s): - Mental Retardation - Neurobehavioral Manifestations - Neurologic Manifestations - Nervous System Diseases - Abnormalities, Multiple - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders
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  Medical image(s) for "De Lange Syndrome"
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Broader term(s): - Nervous System Diseases
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  Medical News for "De Lange Syndrome"
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See also: - Mental Retardation
Broader term(s): - Mental Retardation - Nervous System Diseases - Abnormalities
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  Scientific articles from MEDLINE for "De Lange Syndrome"
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy

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  Clinical Trials for "De Lange Syndrome"
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See also: - Mental Retardation
Broader term(s): - Mental Retardation - Neurobehavioral Manifestations - Neurologic Manifestations - Nervous System Diseases - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy


  Broader term(s):
      Diseases
          Congenital, Hereditary, and Neonatal Diseases and Abnormalities
              Genetic Diseases, Inborn
                  Chromosome Disorders 
              Abnormalities
                  Chromosome Disorders 
                  Abnormalities, Multiple 
      Diseases
          Nervous System Diseases
              Neurologic Manifestations
                  Neurobehavioral Manifestations
                      Mental Retardation 

MeSH 2010 © U.S. National Library of Medicine®.

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