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Charcot-Marie-Tooth Disease
Definition: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

Synonym(s): Atrophy, Muscular, Peroneal / HMSN Type I / HMSN Type II / Hereditary Motor and Sensory-Neuropathy Type II / Hereditary Motor, and Sensory Neuropathy Type I / Muscular Atrophy, Peroneal / Peroneal Muscular Atrophy / Roussy-Levy Syndrome / Charcot-Marie Disease / Charcot-Marie-Tooth Disease, Type I / Charcot-Marie-Tooth Disease, Type II / Charcot-Marie-Tooth Disease, Type Ia / Charcot-Marie-Tooth Disease, Type Ib / HMN Distal Type I / HMSN I / HMSN II / Hereditary Type I Motor and Sensory Neuropathy / Neuropathy, Type I Hereditary Motor and Sensory / Neuropathy, Type II Hereditary Motor and Sensory / Atrophies, Peroneal Muscular / Atrophy, Peroneal Muscular / Charcot Marie Disease / Charcot Marie Tooth Disease / Charcot Marie Tooth Disease, Type I / Charcot Marie Tooth Disease, Type II / Charcot Marie Tooth Disease, Type Ia / Charcot Marie Tooth Disease, Type Ib / HMSN IIs / HMSN Is / HMSN Type IIs / HMSN Type Is / I, HMSN / II, HMSN / IIs, HMSN / IIs, HMSN Type / Is, HMSN / Is, HMSN Type / Muscular Atrophies, Peroneal / Peroneal Muscular Atrophies / Roussy Levy Syndrome / Syndrome, Roussy-Levy / Type IIs, HMSN / Type Is, HMSN
See also:
Myelin P0 Protein  Early Growth Response Protein 2   

MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is Charcot-Marie-Tooth disease?
Charcot-Marie-Tooth disease is a group of progressive disorders that affect the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles as well as sensory cells that detect sensations such as touch, pain, heat, and sound.
Symptoms of Charcot-Marie-Tooth disease usually begin in adolescence or early adulthood, but onset may occur anytime from early childhood to mid-adulthood. Symptoms vary in severity. Some people never realize they have the disorder, but most have a moderate amount of physical disability, and a small percentage ...

How common is Charcot-Marie-Tooth disease?
Charcot-Marie-Tooth disease is the most common inherited disorder that involves the peripheral nerves, affecting an estimated 150,000 people in the United States. It occurs in all races and ethnic groups. Worldwide, this disorder affects about 1 in 3,300 people.


More information from the Genetics Home Reference Website
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view the HON description of the site HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Merwww.asnom.org  
view the HON description of the site HONcode - Charcot-Marie-Tooth disease - Genetics Home Referenceghr.nlm.nih.gov 22
view the robot description of the site List of Diseases: H - RightDiagnosis.comwww.wrongdiagnosis.com  
view the HON description of the site HONcode - Charcot-Marie-Tooth Disease: MedlinePluswww.nlm.nih.gov 2
view the HON description of the site HONcode - Orphanet: Diseases listwww.orpha.net 22
view the robot description of the site Charcot-Marie-Tooth Disease Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)www.ninds.nih.gov 6
view the robot description of the site Charcot-Marie-Tooth disease (hereditary motor sensory neuropathy)www.virtualneurocentre.com  
view the robot description of the site Learning About Charcot-Marie-Tooth Diseasewww.genome.gov  
view the robot description of the site Charcot-Marie-Tooth (CMT) Disease Overview - Charcot-Marie-Tooth Disease - HealthCommunities.comwww.neurologychannel.com 4
view the robot description of the site Charcot-Marie-Tooth (CMT) Disease Overview - Charcot-Marie-Tooth Disease - HealthCommunities.comwww.podiatrychannel.com 4
view the robot description of the site BBC - Health: Charcot-Marie-Tooth disease www.bbc.co.uk  
view the HON description of the site HONcode - Charcot-Marie-Tooth disease (hereditary)www.healthcentral.com  
view the robot description of the site Whonamedit - Charcot-Marie-Tooth diseasewww.whonamedit.com 2
view the robot description of the site rare-diseases — National Organization for Rare Disorderswww.rarediseases.org 2
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See also: - Myelin P0 Protein

Broader term(s): - Hereditary Motor and Sensory Neuropathies - Nervous System Malformations - Nervous System Diseases
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Broader term(s): - Nervous System Diseases
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Broader term(s): - Nervous System Diseases

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Broader term(s): - Hereditary Motor and Sensory Neuropathies - Nervous System Malformations - Nervous System Diseases

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  Broader term(s):
      Diseases
          Congenital, Hereditary, and Neonatal Diseases and Abnormalities
              Genetic Diseases, Inborn
                  Heredodegenerative Disorders, Nervous System
                      Hereditary Motor and Sensory Neuropathies 
              Abnormalities
                  Nervous System Malformations
                      Hereditary Motor and Sensory Neuropathies 
      Diseases
          Nervous System Diseases
              Neuromuscular Diseases
                  Peripheral Nervous System Diseases
                      Polyneuropathies
                          Hereditary Motor and Sensory Neuropathies 
              Neurodegenerative Diseases
                  Heredodegenerative Disorders, Nervous System
                      Hereditary Motor and Sensory Neuropathies 
              Nervous System Malformations
                  Hereditary Motor and Sensory Neuropathies 

MeSH 2010 © U.S. National Library of Medicine®.

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