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Hierarchy  - English - French - German - Spanish - Portuguese - Italian - Dutch    Charcot-Marie-Tooth Disease Definition: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343) Synonym(s): Atrophy, Muscular, Peroneal / HMSN Type I / HMSN Type II / Hereditary Motor and Sensory-Neuropathy Type II / See also: Myelin P0 Protein  Early Growth Response Protein 2    MeSH 2010 © U.S. National Library of Medicine®. Browse - New search

More information from the Genetics Home Reference Website What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease is a group of progressive disorders that affect the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles as well as sensory cells that detect sensations such as touch, pain, heat, and sound. Symptoms of Charcot-Marie-Tooth disease usually begin in adolescence or early adulthood, but onset may occur anytime from early childhood to mid-adulthood. Symptoms vary in severity. Some people never realize they have the disorder, but most have a moderate amount of physical disability, and a small percentage ... How common is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease is the most common inherited disorder that involves the peripheral nerves, affecting an estimated 150,000 people in the United States. It occurs in all races and ethnic groups. Worldwide, this disorder affects about 1 in 3,300 people. More information from the Genetics Home Reference Website © Genetics Home Reference Browse - New search       Web resources for "Charcot-Marie-Tooth Disease"   English (22)  French (1)  German (1)  Spanish (4)    Italian (2)   = Site with HON description   -   = Site with a robot description info: enter the site: (click below) domain of the site:   HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Mer www.asnom.org   HONcode - Charcot-Marie-Tooth disease - Genetics Home Reference ghr.nlm.nih.gov 22 List of Diseases: H - RightDiagnosis.com www.wrongdiagnosis.com   HONcode - Charcot-Marie-Tooth Disease: MedlinePlus www.nlm.nih.gov 2 HONcode - Orphanet: Diseases list www.orpha.net 22 Charcot-Marie-Tooth Disease Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS) www.ninds.nih.gov 6 Charcot-Marie-Tooth disease (hereditary motor sensory neuropathy) www.virtualneurocentre.com   Learning About Charcot-Marie-Tooth Disease www.genome.gov   Charcot-Marie-Tooth (CMT) Disease Overview - Charcot-Marie-Tooth Disease - HealthCommunities.com www.neurologychannel.com 4 Charcot-Marie-Tooth (CMT) Disease Overview - Charcot-Marie-Tooth Disease - HealthCommunities.com www.podiatrychannel.com 4 BBC - Health: Charcot-Marie-Tooth disease www.bbc.co.uk   HONcode - Charcot-Marie-Tooth disease (hereditary) www.healthcentral.com   Whonamedit - Charcot-Marie-Tooth disease www.whonamedit.com 2 rare-diseases — National Organization for Rare Disorders www.rarediseases.org 2 next results See also: - Myelin P0 Protein Broader term(s): - Hereditary Motor and Sensory Neuropathies - Nervous System Malformations - Nervous System Diseases Browse - New search       Medical image(s) for "Charcot-Marie-Tooth Disease" No results for this term. Browse other medical images in HONmedia? Browse - New search       Medical News for "Charcot-Marie-Tooth Disease" No results for this term. More health news Broader term(s): - Nervous System Diseases Browse - New search       Scientific articles from MEDLINE for "Charcot-Marie-Tooth Disease"   - English - French - German - Spanish - Portuguese - Italian - Dutch     All recent articles  Therapy:  by recall    /  by precision  Diagnosis:  by recall    /  by precision  Etiology:  by recall    /  by precision  Prognosis:  by recall    /  by precision Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Browse - New search       Clinical Trials for "Charcot-Marie-Tooth Disease" ClinicalTrials.gov - Linking patients to medical research Ascorbic Acid Treatment in CMT1A Trial (AATIC) Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease High Dose Ascorbic Acid Treatment of CMT1A Follow up and Observation of Charcot Marie Tooth Disease in Families Nerve Entrapment in Diabetic Patients Erythropoietin Spinal Cord Compression Randomized Trial   More results Broader term(s): - Hereditary Motor and Sensory Neuropathies - Nervous System Malformations - Nervous System Diseases Browse - New search       Medical Conferences/Events for "Charcot-Marie-Tooth Disease" No results for this term. Consult HON's world-wide database of medical meetings Browse - New search       Refine the search for  "Charcot-Marie-Tooth Disease" Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy   Broader term(s):       Diseases           Congenital, Hereditary, and Neonatal Diseases and Abnormalities               Genetic Diseases, Inborn                   Heredodegenerative Disorders, Nervous System                       Hereditary Motor and Sensory Neuropathies                Abnormalities                   Nervous System Malformations                       Hereditary Motor and Sensory Neuropathies        Diseases           Nervous System Diseases               Neuromuscular Diseases                   Peripheral Nervous System Diseases                       Polyneuropathies                           Hereditary Motor and Sensory Neuropathies                Neurodegenerative Diseases                   Heredodegenerative Disorders, Nervous System                       Hereditary Motor and Sensory Neuropathies                Nervous System Malformations                   Hereditary Motor and Sensory Neuropathies  MeSH 2010 © U.S. National Library of Medicine®. 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