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Muscular Atrophy, Spinal
Definition: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)

Synonym(s): Bulbospinal Neuronopathy / Kennedy Syndrome / Oculopharyngeal Spinal Muscular Atrophy / Progressive Muscular Atrophy / Scapuloperoneal Form of Spinal Muscular Atrophy / Spinal Muscular Atrophy / Adult Spinal Muscular Atrophy / Bulbo-Spinal Atrophy, X-Linked / Distal Spinal Muscular Atrophy / Myelopathic Muscular Atrophy / Myelopathic Muscular Atrophy, Progressive / Progressive Myelopathic Muscular Atrophy / Progressive Proximal Myelopathic Muscular Atrophy / Proximal Myelopathic Muscular Atrophy, Progressive / Spinal Muscular Atrophy, Distal / Spinal Muscular Atrophy, Oculopharyngeal / Spinal Muscular Atrophy, Scapuloperoneal Form / X-Linked Bulbo-Spinal Atrophy / Atrophies, X-Linked Bulbo-Spinal / Atrophy, Myelopathic Muscular / Atrophy, Spinal Muscular / Atrophy, X-Linked Bulbo-Spinal / Bulbo Spinal Atrophy, X Linked / Bulbo-Spinal Atrophies, X-Linked / Bulbospinal Neuronopathies / Muscular Atrophy, Myelopathic / Neuronopathies, Bulbospinal / Neuronopathy, Bulbospinal / Syndrome, Kennedy / X Linked Bulbo Spinal Atrophy / X-Linked Bulbo-Spinal Atrophies

Narrow term(s):
   Spinal Muscular Atrophies of Childhood

MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is spinal muscular atrophy?
Spinal muscular atrophy is a disorder that affects the control of muscle movement. It is caused by a loss of specialized nerve cells, called motor neurons, in the spinal cord and the part of the brain that is connected to the spinal cord (the brainstem). The loss of motor neurons leads to weakness and shrinkage (atrophy) of muscles used for activities such as crawling, walking, sitting up, and controlling head movement. In severe cases of spinal muscular atrophy, the muscles used for breathing and swallowing are affected.
Spinal muscular atrophy is divide ...

How common is spinal muscular atrophy?
Spinal muscular atrophy affects 1 in 6,000 to 1 in 10,000 people.


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  Web resources for "Muscular Atrophy, Spinal"
  English (26)  French (6)  German (1)  Spanish (3)    Italian (3)  

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view the HON description of the site HONcode - Spinal Muscular Atrophy Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comwww.wrongdiagnosis.com 7
view the HON description of the site HONcode - Spinal muscular atrophy - Genetics Home Referenceghr.nlm.nih.gov 6
view the HON description of the site HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Merwww.asnom.org  
view the HON description of the site HONcode - Spinal Muscular Atrophy: MedlinePluswww.nlm.nih.gov 3
view the HON description of the site HONcode - Spinal Muscular Atrophy Information Page: National Institute of Neurological Disorders and Stroke (NINDS)www.ninds.nih.gov 8
  view the HON description of the site Families of Spinal Muscular Atrophywww.fsma.org 22
view the HON description of the site HONcode - Resveratrol and spinal muscular atrophywww.ricercasma.it 22
view the HON description of the site HONcode - Spinal Muscular Atrophy / Family Villagewww.familyvillage.wisc.edu  
view the HON description of the site HONcode - BBC - Health: Spinal muscular atrophy www.bbc.co.uk  
view the HON description of the site HONcode - Whonamedit - Aran-Duchenne spinal muscular atrophywww.whonamedit.com 7
view the HON description of the site HONcode - EURORDIS - The voice of Rare Disease Patients in Europewww.eurordis.org  
view the HON description of the site HONcode - SMA Foundation | Homewww.smafoundation.org  
view the HON description of the site HONcode - Jennifer Trust for Spinal Muscular Atrophy (JTSMA) | SMAwww.jtsma.org.uk  
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Broader term(s): - Spinal Cord Diseases - Central Nervous System Diseases - Nervous System Diseases - Motor Neuron Disease - Neurodegenerative Diseases - Neuromuscular Diseases
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  Medical image(s) for "Muscular Atrophy, Spinal"
click below to enlargeGenes and disease - Spinal muscular atrophy
www.ncbi.nlm.nih.gov
Copyright © National Center for Biotechnology Information Genes and disease - Spinal muscular atrophy
Broader term(s): - Spinal Cord Diseases
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  Medical News for "Muscular Atrophy, Spinal"
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Broader term(s): - Nervous System Diseases

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  Scientific articles from MEDLINE for "Muscular Atrophy, Spinal"
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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy

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  Clinical Trials for "Muscular Atrophy, Spinal"
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Broader term(s): - Spinal Cord Diseases - Central Nervous System Diseases - Nervous System Diseases - Motor Neuron Disease - Neurodegenerative Diseases - Neuromuscular Diseases

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Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy


  Broader term(s):
      Diseases
          Nervous System Diseases
              Neuromuscular Diseases 
                  Motor Neuron Disease 
              Neurodegenerative Diseases
                  Motor Neuron Disease 
      Diseases
          Nervous System Diseases
              Central Nervous System Diseases
                  Spinal Cord Diseases 

MeSH 2010 © U.S. National Library of Medicine®.

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