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Hierarchy  - English - French - German - Spanish - Portuguese - Italian - Dutch    Angelman Syndrome Definition: A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence "happy"); jerky puppetlike movements (hence "puppet"); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35) Synonym(s): Happy Puppet Syndrome / Puppet Children / Children, Puppet / Syndrome, Angelman / See also: Mental Retardation    MeSH 2010 © U.S. National Library of Medicine®. Browse - New search

More information from the Genetics Home Reference Website What is Angelman syndrome? Angelman syndrome is a complex genetic disorder that affects the nervous system. Characteristic features of this condition include developmental delay or mental retardation, severe speech impairment, seizures, small head size (microcephaly), and problems with movement and balance (ataxia). Delayed development can be noted by 6 months to 12 months of age, and other common signs and symptoms usually become apparent in early childhood. People with Angelman syndrome typically have a happy, excitable demeanor with frequent smiling and laughter, a short attention span, ... How common is Angelman syndrome? Angelman syndrome affects an estimated 1 in 12,000 to 20,000 people. More information from the Genetics Home Reference Website © Genetics Home Reference Browse - New search       Web resources for "Angelman Syndrome"   English (18)  French (3)  German (1)  Spanish (5)  Portuguese (1)     = Site with HON description   -   = Site with a robot description info: enter the site: (click below) domain of the site:   Angelman syndrome Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com www.wrongdiagnosis.com   HONcode - ASNOM - Association Amicale Santé Navale et d'Outre Mer www.asnom.org   Angelman Syndrome Foundation, Inc. – Research, Genetic Counseling, Diagnosis, Seizures, Angelmans Syndrome Association - Angelman www.angelman.org   HONcode - Angelman syndrome - Genetics Home Reference ghr.nlm.nih.gov 4 Angelman Syndrome Information Page: National Institute of Neurological Disorders and Stroke (NINDS) www.ninds.nih.gov 2 HONcode - Medical Dictionary: Happy puppet syndrome - CureResearch.com www.cureresearch.com   Angelman syndrome - MayoClinic.com www.mayoclinic.com   BBC - Health: Angelman syndrome www.bbc.co.uk   Whonamedit - Angelman's syndrome www.whonamedit.com   rare-diseases — National Organization for Rare Disorders www.rarediseases.org   HONcode - Orphanet: Angelman syndrome www.orpha.net 3 Angelmann medgen.genetics.utah.edu   HONcode - Mental retardation www.healthcentral.com   next results See also: - Mental Retardation Broader term(s): - Movement Disorders - Central Nervous System Diseases - Nervous System Diseases - Abnormalities, Multiple - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders Browse - New search       Medical image(s) for "Angelman Syndrome" click below to enlarge medgen.genetics.utah.edu Copyright © Medical Genetics Angelman Syndrome click below to enlarge www.multimania.com Syndrome D'Angelman Possible Controlling area for AS gene Copyright © Charles Williams, M.D. ; Jill Hendrickson, M.S., M.S.S.W.; Elaine Whidden, M.S.N., A.R.N.P. ; Beth Buehler, M.S. Browse - New search       Medical News for "Angelman Syndrome" No results for this term. More health news See also: - Mental Retardation Broader term(s): - Nervous System Diseases - Abnormalities Browse - New search       Scientific articles from MEDLINE for "Angelman Syndrome"   - English - French - German - Spanish - Portuguese - Italian - Dutch     All recent articles  Therapy:  by recall    /  by precision  Diagnosis:  by recall    /  by precision  Etiology:  by recall    /  by precision  Prognosis:  by recall    /  by precision Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Browse - New search       Clinical Trials for "Angelman Syndrome" ClinicalTrials.gov - Linking patients to medical research Study on Tolerability of Levodopa/Carbidopa in Children With Angelman Syndrome Characterization of Angelman Syndrome Dietary Supplements for the Treatment of Angelman Syndrome Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes Genomic Imprinting and Assisted Reproductive Technologies Dietary Supplements for the Treatment of Angelman Syndrome   More results See also: - Mental Retardation Broader term(s): - Movement Disorders - Central Nervous System Diseases - Nervous System Diseases - Abnormalities - Congenital, Hereditary, and Neonatal Diseases and Abnormalities - Chromosome Disorders Browse - New search       Medical Conferences/Events for "Angelman Syndrome" No results for this term. Consult HON's world-wide database of medical meetings Broader term(s): - Movement Disorders Browse - New search       Refine the search for  "Angelman Syndrome" Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy   Broader term(s):       Diseases           Congenital, Hereditary, and Neonatal Diseases and Abnormalities               Genetic Diseases, Inborn                   Chromosome Disorders                Abnormalities                   Chromosome Disorders                    Abnormalities, Multiple        Diseases           Nervous System Diseases               Central Nervous System Diseases                   Movement Disorders  MeSH 2010 © U.S. National Library of Medicine®. Browse - New search

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