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Huntington Disease
Definition: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Synonym(s): Huntington Chorea / Juvenile Huntington Disease / Akinetic-Rigid Variant of Huntington Disease / Chorea, Chronic Progressive Hereditary (Huntington) / Chronic Progressive Hereditary Chorea (Huntington) / Huntington Chronic Progressive Hereditary Chorea / Huntington Disease, Akinetic-Rigid Variant / Huntington Disease, Juvenile / Huntington Disease, Juvenile-Onset / Huntington Disease, Late Onset / Huntington's Chorea / Huntington's Disease / Juvenile-Onset Huntington Disease / Late-Onset Huntington Disease / Progressive Chorea, Chronic Hereditary (Huntington) / Progressive Chorea, Hereditary, Chronic (Huntington) / Akinetic Rigid Variant of Huntington Disease / Chorea, Huntington / Chorea, Huntington's / Huntington Disease, Akinetic Rigid Variant / Huntington Disease, Juvenile Onset / Huntington Disease, Late-Onset / Juvenile Onset Huntington Disease / Late Onset Huntington Disease
MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is Huntington disease?
Huntington disease is a progressive brain disorder that causes uncontrolled movements, mental and emotional problems, and loss of thinking ability (cognition).
Adult-onset Huntington disease, the most common form of this disorder, usually appears in a person's thirties or forties. Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning new information or making decisions. As the disease progresses, involuntary jerking movements (chorea) become more pronounced. Affected individuals may h ...

How common is Huntington disease?
Huntington disease affects an estimated 3 to 7 per 100,000 people of European ancestry. The disorder appears to be less common in some other populations, including people of Japanese, Chinese, and African descent.


More information from the Genetics Home Reference Website
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  Web resources for "Huntington Disease"
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view the HON description of the site HONcode - Huntington disease - Genetics Home Referenceghr.nlm.nih.gov 2
view the robot description of the site Huntington's Disease: Hope Through Research: National Institute of Neurological Disorders and Stroke (NINDS)www.ninds.nih.gov 8
view the HON description of the site HONcode - Huntington's Disease: MedlinePluswww.nlm.nih.gov 2
view the HON description of the site HONcode - Huntington's disease - diet issues | Better Health Channelwww.betterhealth.vic.gov.au 2
view the robot description of the site Huntington's Disease (Huntington Chorea)www.virtualcardiaccentre.com 3
view the robot description of the site BBC - Health: Huntington's disease www.bbc.co.uk  
view the HON description of the site HONcode - Orphanet: Huntington diseasewww.orpha.net 5
view the robot description of the site Learning About Huntington's Diseasewww.genome.gov  
view the HON description of the site HONcode - http://www.healthatoz.com/healthatoz/Ato...www.healthatoz.com  
view the robot description of the site CureHD Foundation; creating awareness and fund-raising to cure Huntington's Diseasewww.curehd.org  
view the robot description of the site Huntington's Disease Advocacy Center - HDAC Home Pagewww.hdac.org  
view the robot description of the site Huntington's Disease Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comwww.wrongdiagnosis.com  
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Broader term(s): - Basal Ganglia Diseases - Brain Diseases - Central Nervous System Diseases - Nervous System Diseases - Dementia - Choreatic Disorders - Movement Disorders - Neurodegenerative Diseases - Delirium, Dementia, Amnestic, Cognitive Disorders - Mental Disorders

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Copyright © Massachusetts General Hospital Huntington's disease (PET)
Broader term(s): - Brain Diseases - Nervous System Diseases - Dementia
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  Scientific articles from MEDLINE for "Huntington Disease"
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  Broader term(s):
      Psychiatry and Psychology
          Mental Disorders
              Delirium, Dementia, Amnestic, Cognitive Disorders
                  Dementia 
                  Cognition Disorders 
      Diseases
          Congenital, Hereditary, and Neonatal Diseases and Abnormalities
              Genetic Diseases, Inborn
                  Heredodegenerative Disorders, Nervous System 
      Diseases
          Nervous System Diseases
              Neurodegenerative Diseases
                  Heredodegenerative Disorders, Nervous System 
              Central Nervous System Diseases
                  Movement Disorders
                      Choreatic Disorders 
                  Brain Diseases
                      Dementia 
      Diseases
          Nervous System Diseases
              Central Nervous System Diseases
                  Brain Diseases
                      Basal Ganglia Diseases 

MeSH 2010 © U.S. National Library of Medicine®.

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