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Colorectal Neoplasms, Hereditary Nonpolyposis
Definition: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes.

Synonym(s): Hereditary Nonpolyposis Colorectal Cancer / Hereditary Nonpolyposis Colorectal Neoplasms / Lynch Syndrome / Colon Cancer, Familial Nonpolyposis / Lynch Cancer Family Syndrome I / Lynch Syndrome I / Lynch Syndrome II / Syndrome, Lynch
MeSH 2010 © U.S. National Library of Medicine®.
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  More information from the Genetics Home Reference Website
What is hereditary nonpolyposis colorectal cancer?
Hereditary nonpolyposis colorectal cancer, often called HNPCC or Lynch syndrome, is a type of inherited cancer of the digestive tract, particularly the colon (large intestine) and rectum. People with hereditary nonpolyposis colorectal cancer have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. Women with this disorder also have a greatly increased risk of endometrial and ovarian cancer. Even though the disorder is described using the term nonpolyposis, peo ...

How common is hereditary nonpolyposis colorectal cancer?
In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of colorectal cancer.


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  Web resources for "Colorectal Neoplasms, Hereditary Nonpolyposis"
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view the HON description of the site HONcode - Lynch syndrome - Genetics Home Referenceghr.nlm.nih.gov 5
view the HON description of the site HONcode - Lynch syndrome - MayoClinic.comwww.mayoclinic.com  
view the robot description of the site BBC - Health: Lynch syndrome www.bbc.co.uk 2
view the robot description of the site Whonamedit - Lynch's syndrome I and IIwww.whonamedit.com  
view the robot description of the site Eyes on the Prize: Frequently Asked Questions about Gynecologic Cancers: Answers from the Pros: Cervical, Endometrial, Ovarian, Uterine, Gestational, Vulvar, Va...www.eyesontheprize.org  
view the HON description of the site HONcode - Hereditary Cancer Program : BC Cancer Agencywww.bccancer.bc.ca  
view the robot description of the site Genomics|Update|Currentwww.cdc.gov 2
view the robot description of the site Colon Cancer | MD Anderson Cancer Centerwww.mdacc.tmc.edu  
view the robot description of the site Annals of Internal Medicine | Page Not Found www.annals.org  
view the robot description of the site Genetic Health Glossarywww.genetichealth.com 2
view the robot description of the site Katie Couric Colon Cancer Shows...www.coloncancerresource.com  
view the HON description of the site HONcode - http://www.healthatoz.com/healthatoz/Ato...www.healthatoz.com 9
view the HON description of the site HONcode - Printed Resourceswww.ped-onc.org  
 
 

Broader term(s): - Colorectal Neoplasms - Intestinal Neoplasms - Gastrointestinal Neoplasms - Digestive System Neoplasms - Neoplasms - Neoplastic Syndromes, Hereditary - Metabolic Diseases - Nutritional and Metabolic Diseases

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  Medical image(s) for "Colorectal Neoplasms, Hereditary Nonpolyposis"
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Broader term(s): - Colorectal Neoplasms - Intestinal Neoplasms - Neoplasms
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  Medical News for "Colorectal Neoplasms, Hereditary Nonpolyposis"
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Broader term(s): - Colorectal Neoplasms - Neoplasms

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  Scientific articles from MEDLINE for "Colorectal Neoplasms, Hereditary Nonpolyposis"
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  Clinical Trials for "Colorectal Neoplasms, Hereditary Nonpolyposis"
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Broader term(s): - Colorectal Neoplasms - Intestinal Neoplasms - Gastrointestinal Neoplasms - Digestive System Neoplasms - Neoplasms - Metabolic Diseases

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  Broader term(s):
      Diseases
          Nutritional and Metabolic Diseases
              Metabolic Diseases
                  DNA Repair-Deficiency Disorders 
      Diseases
          Congenital, Hereditary, and Neonatal Diseases and Abnormalities
              Genetic Diseases, Inborn
                  Neoplastic Syndromes, Hereditary 
      Diseases
          Digestive System Diseases
              Gastrointestinal Diseases
                  Intestinal Diseases
                      Intestinal Neoplasms
                          Colorectal Neoplasms 
                      Colonic Diseases
                          Colorectal Neoplasms 
                  Gastrointestinal Neoplasms
                      Intestinal Neoplasms
                          Colorectal Neoplasms 
      Diseases
          Digestive System Diseases
              Digestive System Neoplasms
                  Gastrointestinal Neoplasms
                      Intestinal Neoplasms
                          Colorectal Neoplasms 
      Diseases
          Neoplasms
              Neoplastic Syndromes, Hereditary 
              Neoplasms by Site
                  Digestive System Neoplasms
                      Gastrointestinal Neoplasms
                          Intestinal Neoplasms
                              Colorectal Neoplasms 

MeSH 2010 © U.S. National Library of Medicine®.

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