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Anticlotting Drugs and Pregnancy
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The previously reported high frequency of adverse effects
of heparin is explained by maternal comorbid conditions (pre-eclampsia,
glomerulonephritis, placental insufficiency) that independently are associated
with adverse effects. Heparin is considered to be safe during pregnancy
for either the prevention or treatment of thromboembolic disease.
The administration of Low molecular
weight heparins during pregnancy is safe for both the mother and
the foetus. The absence of teratogenic effects, a predictable anticoagulation,
easy administration and lack of need for laboratory monitoring make them
preferable for thromboembolism during pregnancy.
Oral anticoagulants (coumarin) cross the
placenta and can enter the foetal circulation.The following problems are
associated with the use of coumarin during pregnancy: embryopathy, central
nervous system defects, ,
,
and
The characteristics of foetal warfarin syndrome
associated with first trimester exposure to coumarin are nasal hypoplasia
due to maldevelopment of the nasal septum and stippled epiphyses, depression
of the nasal bridge with a flattened upturned appearance. Eye defects,
seizures, deafness, congenital heart disease, and hypoplasia of the extremities
have all been reported.
Exposure to warfarin during any trimester has resulted in central nervous
system abnormalities.
For further, more detailed information, consult the reference
source for this page.
The information in this page is presented in summarised form and has been taken
from the following source(s):
1.
Motherisk, The Hospital for Sick Children:
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Introduction
